Long-gene transcript bias
Gene co-expression module in Enterocytes
| Category | Technical artifact |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Heterogeneous set of long genes: APC, MAP3K2, PALS1, KLHL24 and TRHDE. The epithelial metabolic genes CYP2C9 and PLA2G4C are peripheral. There is no coherent program, possibly nuclear-transcript or long-gene capture bias. APC and PALS1 weakly suggest epithelial polarity/Wnt control.
Genes
APC, CNGA1, CYP2C9, KLHL24, MAP3K2, PALS1, PLA2G4C, TRHDE
Most correlated modules
- Enterocyte lipid trafficking · correlation 0.88
- Chylomicron apolipoprotein assembly · correlation 0.84
- Mature enterocyte differentiation · correlation 0.82
- Brush border lipid handling · correlation 0.79
- Crypt-top colonocyte · correlation 0.79
- Colonocyte differentiation TFs · correlation 0.77
- Long-gene transcript bias · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.