MAP3K2 — Mitogen-activated protein kinase kinase kinase 2
MAP3K2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP3K2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene transcript bias Technical artifact | APC, CNGA1, CYP2C9, KLHL24, PALS1, PLA2G4C, TRHDE | View in SCUBA |
| Gamma-delta T cells | MAPK Kinase Signaling TCR Signaling | ARIH1, B4GALT1, BRAF, CDK16, CHD1, DYRK1A, GNA13, KDM2A +8 more | |
| Macrophages | Endolysosomal Trafficking Vesicular traficking | ANKRD10, ATP1A1, ATP6V0A1, CHFR, CHML, FAR1, FBXL5, GSAP +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Activation Signaling TCR Signaling | ARFGEF1, ARIH1, CARD11, CCDC88C, CD226, GLS, KANSL1, KMT5B +12 more | |
| Neutrophils | Neutrophil Survival FOXO-MK2 Developmental | ARIH1, FCAR, FGD4, FOXO3, HECA, IPMK, MAPKAPK2, RAB8B +1 more |
About the gene
| Synonyms | MEKK2, MEKK2B |
|---|---|
| Chromosome | 2: 127298668-127388465 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and- run dynamics.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.