Brush border lipid handling
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Enterocyte brush border and lipid efflux program. CDHR2 forms brush border intermicrovillar links and ENTPD8 is an apical ectonucleotidase. ABCG1 performs cholesterol efflux, PNPLA2 triglyceride lipolysis, ABHD12 lipase activity, and IDS lysosomal degradation. The lipid genes link this module to M28 and M56.
Genes
ABCG1, ABHD12, ARL14, CDHR2, ENTPD8, IDS, PNPLA2, RAI14, SEMA3G, SUCO, TBX3
Most correlated modules
- Endocytic nutrient uptake · correlation 0.90
- Chylomicron apolipoprotein assembly · correlation 0.88
- ER-autophagy homeostasis · correlation 0.88
- JUN stress response · correlation 0.86
- Crypt-top colonocyte · correlation 0.85
- Mature enterocyte differentiation · correlation 0.83
- TNF receptor signaling · correlation 0.83
- Surface colonocyte lipid-droplet · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.