Colonocyte differentiation TFs
Gene co-expression module in Enterocytes
| Category | Chromatin regulation & transcription |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
NR3C2 (the mineralocorticoid receptor, which drives distal colonic sodium absorption), HNF4G, SOX6 and LCORL are transcription factors of differentiated colonocytes. JMJD1C and ATXN1 are chromatin and transcription regulators. The trafficking genes (DENND1B, RABGAP1L, AGAP1, GOLIM4) and other long genes point to a broadly expressed differentiation-TF program.
Genes
AGAP1, ATXN1, DENND1B, DOCK5, GOLIM4, GRAMD2B, HNF4G, JMJD1C, LCORL, NR3C2, RABGAP1L, SIPA1L3, SOX6, SSH2, TMEM117, TULP4
Most correlated modules
- Long-gene Nuclear Transcripts · correlation 0.78
- Long-gene transcript bias · correlation 0.77
- Long-gene transcript bias · correlation 0.72
- Apical junction complex · correlation 0.69
- Apicobasal polarity scaffold · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.