STAT3/JNK signaling
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
STAT3, MAPK8 (JNK1), PELI1, STK24, ETV6 and CDC42SE2 indicate cytokine/STAT3 and JNK signaling. This fits the IL-6/IL-22-driven epithelial response, which is consistent with IL6ST in the neighboring M83. LRRC1 and PDLIM5 connect to polarity and the cytoskeleton.
Genes
CDC42SE2, ETV6, KIAA0232, LRRC1, MAPK8, PDLIM5, PELI1, STAT3, STK24
Most correlated modules
- Basal adhesion remodeling · correlation 0.91
- Inflammatory cell death · correlation 0.89
- NF-kB epithelial activation · correlation 0.88
- Colonocyte terminal differentiation · correlation 0.86
- IFN-gamma response · correlation 0.85
- Long-gene nuclear transcripts · correlation 0.84
- Inflammatory hypoxic response · correlation 0.81
- Long-gene nuclear transcripts · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.