DUOX2 oxidative defense
Gene co-expression module in Enterocytes
| Category | Antibacterial |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
DUOX2 and DUOXA2 form the epithelial H2O2-generating host-defense system, induced by microbial and IFN signals in colitis. CD55, CEACAM5 and ITGA2 are inflammation-associated surface genes. HK2 reflects a glycolytic shift. Together these give the classic IBD-inflamed colonocyte DUOX2 signature, which fits alongside the IFN neighbors.
Genes
CD55, CEACAM5, DUOX2, DUOXA2, ENSG00000267881, HK2, ITGA2, TPM4
Most correlated modules
- Epithelial junction adhesion · correlation 0.89
- Inflammatory cell death · correlation 0.80
- Epithelial NF-kB response · correlation 0.78
- IFN-gamma STAT1 signaling · correlation 0.69
- Basal adhesion remodeling · correlation 0.66
- IFN-gamma immunoproteasome · correlation 0.63
- Actin cytoskeleton · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.