Basal adhesion remodeling
Gene co-expression module in Enterocytes
| Category | Migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
ITGA6, EPB41L2, FNDC3B, SESTD1, SH3RF1 and ETS2 reflect basolateral adhesion, cytoskeletal remodeling and migration of epithelium, as occurs during restitution. SPATS2L and HERC4 are mildly stress-responsive. SGMS1 and NT5C2 are metabolic genes. The module is broad but centers on adhesion.
Genes
EPB41L2, ETS2, FNDC3B, HERC4, ITGA6, NT5C2, SESTD1, SGMS1, SH3RF1, SLMAP, SPATS2L
Most correlated modules
- STAT3/JNK signaling · correlation 0.91
- Colonocyte terminal differentiation · correlation 0.84
- NF-kB epithelial activation · correlation 0.83
- Inflammatory cell death · correlation 0.81
- EGFR wound response · correlation 0.81
- IFN-gamma response · correlation 0.81
- Inflammatory hypoxic response · correlation 0.80
- Stress-responsive transcription · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.