NF-kB epithelial activation
Gene co-expression module in Enterocytes
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
NFKBIA, CCL20, TRIM31, IL6ST, BIRC-like survival genes and TMPRSS2 indicate NF-kB/cytokine-driven epithelial activation. CCL20 is a classic NF-kB target in colonocytes, and IL6ST is the gp130 subunit for IL-6-family signaling. TRIM31 regulates inflammasome activity and NF-kB. RAB8B and EHD4 are vesicle-trafficking genes co-induced with this program. It neighbors the IFN (M31) and STAT3 (M66) modules.
Genes
BNIP5, CCL20, EHD4, HPS5, IL6ST, NFKBIA, RAB8B, RAP1B, TMPRSS2, TRIM31
Most correlated modules
- Inflammatory hypoxic response · correlation 0.89
- STAT3/JNK signaling · correlation 0.88
- EGFR wound response · correlation 0.86
- Basal adhesion remodeling · correlation 0.83
- IFN-gamma response · correlation 0.82
- Inflammatory cell death · correlation 0.81
- Stress-responsive transcription · correlation 0.81
- Colonocyte terminal differentiation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.