ER Stress UPR

Gene co-expression module in Fibroblasts

View this module in SCUBA

Why this annotation

NNMT (nicotinamide N-methyltransferase) is a metabolic enzyme highly expressed in activated fibroblasts and linked to epigenetic regulation and inflammatory fibroblast states. RELB is a non-canonical NF-κB subunit involved in inflammatory gene regulation. XBP1 is a master regulator of the unfolded protein response (UPR)/ER stress. LDHA encodes lactate dehydrogenase A, a key glycolytic enzyme upregulated in metabolic stress. UGCG encodes ceramide glucosyltransferase involved in sphingolipid metabolism. LITAF is a transcription factor that induces TNF and other inflammatory cytokines. TNFRSF10B (DR5) is a death receptor for TRAIL involved in apoptosis. BTG3 is an anti-proliferative gene. CYCS (cytochrome c) is a mitochondrial apoptosis mediator. B4GALT1 is a glycosyltransferase. ELOC is a ubiquitin ligase component. The module is upregulated in UC and CD inflammation. The combination of XBP1, NNMT, RELB, LDHA, and LITAF suggests an ER stress/UPR-linked inflammatory metabolic program in fibroblasts.

Genes

ARF4, B4GALT1, BTG3, BZW1, CYCS, EFHD2, ELOC, LDHA, LITAF, NNMT, RELB, RPL22L1, TNFRSF10B, UGCG, XBP1

Most correlated modules

• AP-1 Inflammatory Stress · correlation 0.91
• Inflammatory Fibroblast Activation · correlation 0.91
• Hypoxia Response · correlation 0.85
• NF-κB Stress Response · correlation 0.82
• Hypoxia Metabolic Stress · correlation 0.82
• Inflammatory ECM Remodeling · correlation 0.78
• NFAT-cAMP Signaling · correlation 0.77
• NF-κB Inflammatory Activation · correlation 0.74

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.