Inflammatory Fibroblast Activation
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes include PDPN (podoplanin, marker of inflammatory/activated fibroblasts), TNFRSF12A (TWEAK receptor, promotes fibroblast activation and inflammation), TMEM158 (RAS-induced senescence/activation marker), MAPKAPK2 (p38 MAPK downstream kinase, stress/inflammatory signaling), ITGA5 (fibronectin receptor, migration/activation), PLAUR (uPAR, co-expressed with PLAU in M38 neighbor, inflammation), HSPA5 (ER stress chaperone), and SELENOS (ER stress/selenium). The strong upregulation in UC and CD inflammation and neighbor relationship with M38 (hypoxia/inflammation) supports this as an inflammatory fibroblast activation state. PDPN and TNFRSF12A are canonical markers of inflammatory CAF-like fibroblasts in IBD.
Genes
CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, PLAUR, SELENOS, SUSD6, TMEM158, TNFRSF12A, TUBA1C
Most correlated modules
- Hypoxia Response · correlation 0.92
- ER Stress UPR · correlation 0.91
- AP-1 Inflammatory Stress · correlation 0.89
- Lysosomal Stress Response · correlation 0.88
- Inflammatory ECM Remodeling · correlation 0.88
- Proteasome Biogenesis · correlation 0.87
- Activated Myofibroblast State · correlation 0.82
- NFAT-cAMP Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.