Hypoxia Metabolic Stress
Gene co-expression module in Fibroblasts
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
SERPINE1 (PAI-1) is a canonical hypoxia/HIF-1α and inflammatory target involved in fibrinolysis inhibition. PFKFB3 is a key glycolytic enzyme strongly induced by HIF-1α under hypoxia. HMOX1 is a classic oxidative stress and hypoxia-inducible gene. PIM1 is a pro-survival kinase induced by cytokines and hypoxia. TRIB1 is a stress-responsive pseudokinase. NFATC1 is a transcription factor activated by calcium/inflammatory signals. DYRK3 regulates stress granule dissolution and mTOR under hypoxia. EMP1 is induced in inflammatory/hypoxic contexts. WTAP is an m6A methyltransferase with roles in hypoxic gene regulation. ERRFI1 (MIG6) is an EGFR feedback inhibitor induced by stress. ABL2 is a tyrosine kinase involved in stress signaling. The module is strongly upregulated in both UC and CD inflammation. The combination of PFKFB3, SERPINE1, HMOX1, and DYRK3 strongly points to a hypoxia/metabolic stress program in inflamed fibroblasts.
Genes
ABL2, DYRK3, EMP1, ERRFI1, HMOX1, NFATC1, PFKFB3, PIM1, SERPINE1, TRIB1, WTAP, ZBTB21
Most correlated modules
- NF-κB Stress Response · correlation 0.92
- AP-1 Inflammatory Stress · correlation 0.87
- ER Stress UPR · correlation 0.82
- Cytokine Inflammatory Response · correlation 0.81
- Integrated Stress Response · correlation 0.79
- NF-κB Epigenetic Reprogramming · correlation 0.75
- Proteotoxic Stress Survival · correlation 0.73
- Cytokine Chemokine Secretion · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.