Inflammatory Fibroblast Activation
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
RUNX1 and ETS2 are transcription factors activated in inflammatory fibroblasts; VEGFA drives angiogenesis in inflamed tissue; TGFB1 is a master fibrosis/inflammation cytokine; CTNNB1 (beta-catenin) integrates Wnt and inflammatory signals; PRDM1 (BLIMP1) is a transcriptional repressor involved in fibroblast-to-myofibroblast transition; PTX3 is an acute-phase pentraxin upregulated in inflamed stroma; BAMBI is a BMP/TGF-beta pseudoreceptor; SPRY4 provides negative feedback on RTK/MAPK signaling; CRISPLD2 is an LPS-binding protein with anti-inflammatory roles. This module represents a transcriptionally activated inflammatory fibroblast state, strongly associated with UC remission (possibly reflecting residual activation or repair).
Genes
ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, ETS2, F2RL3, FILIP1L, GABARAPL1, HOMER1, MCTP2, PRDM1, PTX3, RUNX1, SLC30A1, SPRY4, TGFB1, VEGFA
Most correlated modules
- IL-1 Receptor Signaling · correlation 0.84
- Thrombin Receptor Signaling · correlation 0.82
- Wnt-BMP Fibroblast · correlation 0.81
- TGF-beta Fibrosis · correlation 0.80
- Hypoxia Response · correlation 0.80
- NFAT-cAMP Signaling · correlation 0.72
- AP-1 Inflammatory Stress · correlation 0.70
- MMP-driven Fibroblast Remodeling · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.