Inflammatory ECM Remodeling
Gene co-expression module in Fibroblasts
| Category | ECM remodeling |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include SNX10 (sorting nexin, lysosomal/endosomal trafficking), COTL1 (actin-binding, inflammation), CHI3L1 (chitinase-3-like-1, a well-known marker of activated stromal/macrophage-like cells in IBD inflammation), CD82 (tetraspanin, cell adhesion/signaling), SLC39A14 (zinc transporter, acute phase/inflammation), ADAMTS2 (ECM protease), PTGES (prostaglandin E synthase, inflammatory lipid mediator), MT2A (metallothionein, stress/metal response), NID2 (nidogen-2, ECM). The strongest delta_inflammation scores in the batch (UC: 1.113, CD: 0.783) and reversal in remission. CHI3L1 and PTGES are strong inflammatory markers; ADAMTS2 and NID2 suggest ECM remodeling context. This module reflects an inflammatory ECM-remodeling fibroblast state with prostaglandin production.
Genes
ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, LXN, MT2A, NID2, PTGES, RAI14, SLC39A14, SNX10, TMEM132A
Most correlated modules
- Activated Myofibroblast State · correlation 0.90
- Lysosomal Stress Response · correlation 0.88
- Inflammatory Fibroblast Activation · correlation 0.88
- Inflammatory Fibroblast Activation · correlation 0.80
- Hypoxia Response · correlation 0.79
- ER Stress UPR · correlation 0.78
- OSM Cytokine Response · correlation 0.76
- AP-1 Inflammatory Stress · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.