Quiescent Anti-inflammatory Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
TXNIP (metabolic/oxidative stress sensor, anti-inflammatory), RCAN2 (calcineurin inhibitor, thyroid hormone response), PITX1 (hindgut positional TF), IGFBP3 (growth arrest/quiescence), ADIRF (adipogenic differentiation), NDRG2 (stress-induced differentiation), and DACH1 (developmental TF) together define a metabolically quiescent, anti-inflammatory fibroblast state. Significantly downregulated in inflammation and strongly restored in remission, consistent with a homeostatic fibroblast program suppressed by IBD inflammation.
Genes
ADIRF, CHCHD10, DACH1, FXYD6, IGFBP3, KHDRBS3, LSP1, NDRG2, PDE1A, PITX1, RCAN2, TXNIP
Most correlated modules
- Homeostatic Stromal Identity · correlation 0.59
- Retinoid Stromal Quiescence · correlation 0.50
- OSR1+ Deep Fibroblast · correlation 0.42
- COL13A1+ Deep Fibroblast · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.