TCF7L2 — Transcription factor 7 like 2
TCF7L2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TCF7L2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene nuclear transcripts Technical artifact | ANKRD12, CEMIP2, EPS8, ETNK1, GCC2, MYO1E, SLC2A13 | View in SCUBA |
| Fibroblasts | OSR1+ Deep Fibroblast Developmental | EMCN, EPHA3, HS3ST6, ID4, OMG, OSR1, PCLO, PPP1R1B +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Multipotent Progenitor Identity Stemness | BCL11A, BTG2, DOCK1, DUSP6, MN1, NLRP1, PTPRE, SEPTIN9 +2 more | |
| Macrophages | Transcriptional Regulation Housekeeping | ABCC4, ARHGAP12, ATP8B4, CBFA2T2, DLG1, FAM168A, FBXO42, FCHO2 +20 more | View in SCUBA |
| Monocytes | Non-classical Monocyte Innate immunity | CD79B, CDH23, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2 +6 more | View in SCUBA |
About the gene
| Synonyms | TCF-4, TCF4 |
|---|---|
| Chromosome | 10: 112950247-113167678 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.