Subepithelial Fibroblast Identity
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 21 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes SFRP1 (Wnt antagonist), NR2F2 (nuclear receptor marking subepithelial fibroblasts), ECM2, EFEMP1, SLIT3, ANGPTL1, and CNTN1 define a stromal fibroblast identity program with Wnt-inhibitory and ECM-regulatory features. NR2F2 is a well-established marker of intestinal subepithelial myofibroblasts/fibroblasts. SFRP1 suppresses Wnt to maintain stromal quiescence. Downregulated in inflammation, restored in remission — consistent with a homeostatic subepithelial fibroblast state.
Genes
ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A, FGF13, LPAR4, LURAP1L, MARCKS, MUSK, MYO16, NR2F2, PTPRD, SFRP1, SLIT3, TNFAIP8L3, TNFSF13B, ZNF385A
Most correlated modules
- Quiescent Stromal Identity · correlation 0.91
- Elastin-Fibronectin ECM · correlation 0.86
- Wnt-niche Fibroblast · correlation 0.81
- Microfibril ECM Fibroblast · correlation 0.79
- OSR1+ Deep Fibroblast · correlation 0.79
- Elastic Fiber ECM · correlation 0.77
- BMP-antagonizing Fibroblast · correlation 0.75
- Neural-crest Fibroblast · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.