Elastin-Fibronectin ECM
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes S100A4 (canonical fibroblast marker), ELN (elastin, structural ECM), FN1 (fibronectin, major ECM glycoprotein), SERPINE2 (serine protease inhibitor/ECM regulator), SOD3 (extracellular antioxidant), and ABI3BP (ECM-associated protein) define a fibroblast ECM production program. ELN and FN1 are core structural ECM components; SERPINE2 regulates ECM turnover. S100A4 marks activated/motile fibroblasts. This module represents an ECM-producing fibroblast state, consistent with the neighbor context of stromal identity modules.
Genes
ABI3BP, DDAH2, ELN, FN1, LRIG3, S100A4, SERPINE2, SOD3, SSC5D
Most correlated modules
- Subepithelial Fibroblast Identity · correlation 0.86
- Quiescent Stromal Identity · correlation 0.84
- Microfibril ECM Fibroblast · correlation 0.79
- Wnt-Niche Fibroblast · correlation 0.73
- OSR1+ Deep Fibroblast · correlation 0.71
- Wnt-niche Fibroblast · correlation 0.70
- Homeostatic Fibroblast Identity · correlation 0.69
- Elastic Fiber ECM · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.