Lysosomal Biogenesis
Gene co-expression module in Fibroblasts
| Category | Vesicular traficking |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
This is a tightly coherent (core) module with high expression (38.2% positive). The hub genes are overwhelmingly lysosomal: OS9 (ER lectin involved in ERAD/glycoprotein quality control), PLD3 (lysosomal phospholipase D), GRN (granulin/progranulin, lysosomal protein critical for lysosomal homeostasis), HEXA (lysosomal beta-hexosaminidase A), PSAP (prosaposin, lysosomal sphingolipid activator), SCARB2 (lysosomal integral membrane protein LIMP-2), CPQ (lysosomal carboxypeptidase Q), CST3 (cystatin C, cysteine protease inhibitor), LGALS3BP (galectin-3 binding protein, secreted/lysosomal). APP (amyloid precursor protein) is processed in the endolysosomal pathway. GLG1 (Golgi glycoprotein 1) and ATRAID (all-trans retinoic acid-induced differentiation factor, lysosomal) complete the picture. This module represents constitutive lysosomal biogenesis and function in intestinal fibroblasts, a neighbor of M34 which also has lysosomal components.
Genes
APP, ATRAID, CPQ, CST3, GLG1, GRN, HEXA, LGALS3BP, NDN, OS9, PLD3, PSAP, SCARB2, SERPINF1
Most correlated modules
- Lysosomal Cytoskeletal · correlation 0.81
- Translation Initiation · correlation 0.80
- Collagen ECM Production · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.