NDN — Necdin, MAGE family member
NDN belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ADAM23, AGPAT2, CLDN5, ECHDC2, GOLGA8B, HHEX, LY6E, PERP +1 more | View in SCUBA |
| Fibroblasts | Lysosomal Biogenesis Vesicular traficking | APP, ATRAID, CPQ, CST3, GLG1, GRN, HEXA, LGALS3BP +5 more | View in SCUBA |
About the gene
| Synonyms | HsT16328, PWCR |
|---|---|
| Chromosome | 15: 23685400-23687305 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Growth regulation, Transcription, Transcription regulation |
Function
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.