Lysosomal Cytoskeletal
Gene co-expression module in Fibroblasts
| Category | Vesicular traficking |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
SDC2 (syndecan-2, a transmembrane heparan sulfate proteoglycan important for cell-matrix adhesion and signaling) is the top hub gene. PPT1 (palmitoyl-protein thioesterase-1, lysosomal enzyme) and SCPEP1 (lysosomal serine carboxypeptidase) indicate lysosomal activity. WASF2 (WAVE2, Arp2/3 complex activator for actin branching) and PLS3 (plastin-3, actin bundling protein) indicate cytoskeletal regulation. MAGED2 (melanoma antigen family D2) is expressed in stromal cells. The module is a neighbor of M112 (lysosomal program) and M23 (metabolic), suggesting a shared vesicular/lysosomal neighborhood. The combination of SDC2-mediated matrix sensing with lysosomal processing and actin remodeling may reflect endocytic/recycling activity in fibroblasts.
Genes
C7orf50, FBXO21, LHFPL6, MAGED2, PLS3, PPT1, SCPEP1, SDC2, TTC3, WASF2
Most correlated modules
- Actin Cytoskeletal Organization · correlation 0.86
- Basement Membrane ECM · correlation 0.85
- Rho-ROCK Contractility · correlation 0.83
- Metabolic Homeostasis · correlation 0.82
- Lysosomal Biogenesis · correlation 0.81
- Caveolae Mechanosensing · correlation 0.80
- TGF-beta Response · correlation 0.76
- Telocyte Identity Program · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.