Translation Initiation
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include CNBP (CCHC-type zinc finger, RNA-binding/translational regulator), PEBP1 (phosphatidylethanolamine-binding protein, Raf kinase inhibitor), CCNI (cyclin I, involved in cell survival), ESD (esterase D), LAPTM4A (lysosomal protein transmembrane 4A), EIF3F and EIF3E (eukaryotic initiation factor 3 subunits), SOD1 (superoxide dismutase), ITM2B (integral membrane protein 2B), CD99, HNRNPA1 (heterogeneous nuclear ribonucleoprotein), and SEC62 (ER translocation). The module is core coherent with uniform expression. The combination of EIF3 subunits, HNRNPA1, CNBP, and SEC62 points to general translational/ER protein processing housekeeping. SOD1 adds an oxidative stress defense component. This is a general housekeeping/translation-support module. Neighbor context: sits adjacent to ribosomal modules (M121, M69, M29, M8), consistent with a housekeeping translation program.
Genes
CCNI, CD99, CNBP, EIF3E, EIF3F, ESD, HNRNPA1, ITM2B, LAPTM4A, PEBP1, SEC62, SOD1
Most correlated modules
- Ribosome Biogenesis · correlation 0.93
- ER-Golgi Trafficking · correlation 0.87
- WAVE-RAC1 Actin · correlation 0.87
- Complement-secreting Fibroblast · correlation 0.82
- Lysosomal Biogenesis · correlation 0.80
- ECM Homeostasis · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.