SERPINF1 — Serpin family F member 1
SERPINF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERPINF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lysosomal Biogenesis Vesicular traficking | APP, ATRAID, CPQ, CST3, GLG1, GRN, HEXA, LGALS3BP +5 more | View in SCUBA |
| Macrophages | Antimicrobial Oxidative Defense Antibacterial | ADAMDEC1, ALDOA, APOL3, CALHM6, CLEC10A, COX16, CPVL, DEFA5 +30 more | View in SCUBA |
| Monocytes | M2 Macrophage Polarization Innate immunity | AHNAK, CRTAP, F13A1, GLDN, GSN, IDH1, IL13RA1, LDHB +7 more | View in SCUBA |
| Pericytes | Inflammatory Pericyte Activation Developmental | CDH11, CHN1, EGFL6, NNMT, PROCR, PRRX1, TDO2, TYMP | View in SCUBA |
| Smooth muscle cells | Adhesion Activation Migration & adhesion | ANXA2, ATP1B3, CAPNS1, CD44, CYBRD1, FHL2, LAMC1, LGALS3 +3 more | View in SCUBA |
About the gene
| Synonyms | EPC-1, PEDF, PIG35 |
|---|---|
| Chromosome | 17: 1762029-1777565 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.