SCARB2 — Scavenger receptor class B member 2
SCARB2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCARB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-κB Stress Signaling Inflammation | AKR1C3, ELK4, EPS15, METRNL, MYCBP2, NFAT5, PALM, PELI2 +4 more | View in SCUBA |
| Fibroblasts | Lysosomal Biogenesis Vesicular traficking | APP, ATRAID, CPQ, CST3, GLG1, GRN, HEXA, LGALS3BP +5 more | View in SCUBA |
| Lymphatic endothelial | Antigen Presentation IFN Inflammation | ADAR, GPRC5B, HLA-F, KTN1, PARP14, PTTG1IP, TAPBP, TMEM123 +2 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CANX, CAPZA1, CD164, CMTM6, COPB1, EXOC5 +18 more | View in SCUBA |
| Monocytes | Tissue Macrophage Identity Tissue homeostasis | CMKLR1, CREBL2, CSF1R, DST, EPB41L2, SLC46A1, SNX5 | View in SCUBA |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9 +5 more | View in SCUBA |
About the gene
| Synonyms | CD36L2, HLGP85, LIMP-2, LIMPII, SR-BII |
|---|---|
| Chromosome | 4: 76158737-76234536 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Host-virus interaction |
Function
Acts as a lysosomal receptor for glucosylceramidase (GBA1) targeting. (Microbial infection) Acts as a receptor for enterovirus 71
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.