BMP-Wnt Fibroblast Program
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include BMP5 (BMP morphogenetic signaling), TBX2 (developmental transcription factor), DAAM2 (formin effector of Wnt/planar cell polarity, actin nucleation), GMFG (actin dynamics regulator), CTSD (lysosomal cathepsin D), ENPP6 (lysophospholipase), and ACP5 (acid phosphatase). BMP5 and TBX2 are developmental regulators; DAAM2 links Wnt signaling to cytoskeletal remodeling. The module is downregulated in inflammation and recovers in remission. As a topological neighbor of M115 (which contains SCUBE2, a BMP co-receptor) and M64 (which contains BMP2), this module likely represents a BMP-driven developmental/morphogenetic fibroblast program. The combination of BMP signaling, Wnt effectors, and lysosomal activity suggests active tissue patterning in quiescent fibroblasts.
Genes
ACP5, BMP5, CTSD, CTXND1, DAAM2, ENPP6, GMFG, TBC1D2B, TBX2
Most correlated modules
- Lamina Propria ECM · correlation 0.81
- Intestinal Fibroblast Identity · correlation 0.76
- Telocyte Identity Program · correlation 0.76
- Wnt-BMP Fibroblast · correlation 0.74
- WNT-modulating Fibroblast · correlation 0.73
- COL13A1+ Deep Fibroblast · correlation 0.64
- CYGB+ Quiescent Fibroblast · correlation 0.62
- Fibroblast Niche Identity · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.