Intestinal Fibroblast Identity
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include CAMK4 (calcium signaling kinase), ENPP2 (autotaxin/LPA production), GLP2R (intestinal subepithelial fibroblast marker GPCR), RGS6 (G-protein regulator), PRKCQ (PKC theta signaling), DSE (dermatan sulfate ECM), and SEMA3A (semaphorin guidance). The module is strongly downregulated during intestinal inflammation (UC/CD) and recovers in remission, consistent with a quiescent intestinal fibroblast identity program. GLP2R is a well-established marker of intestinal subepithelial myofibroblasts/fibroblasts. The LPA signaling axis (ENPP2/LPAR) and calcium-dependent kinase signaling (CAMK4, PRKCQ) define a specialized fibroblast signaling state. Neighbor M64 also contains LPAR3, reinforcing the LPA signaling theme across this batch.
Genes
ABR, AFF3, ATP8A1, ATP9A, CAMK4, DSE, ENPP2, GLP2R, MRPS6, NRIP3, PRKCQ, REEP2, RGS6, SCUBE2, SEMA3A, TOX
Most correlated modules
- WNT-modulating Fibroblast · correlation 0.92
- Fibroblast Niche Identity · correlation 0.88
- Myofibroblast Subtype · correlation 0.84
- Lamina Propria ECM · correlation 0.83
- Telocyte Identity Program · correlation 0.80
- BMP-Wnt Fibroblast Program · correlation 0.76
- Caveolae Mechanosensing · correlation 0.75
- ECM Glycan Remodeling · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.