ENPP6 — Ectonucleotide pyrophosphatase/phosphodiesterase 6
ENPP6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENPP6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Fibroblasts | BMP-Wnt Fibroblast Program Developmental | ACP5, BMP5, CTSD, CTXND1, DAAM2, GMFG, TBC1D2B, TBX2 | View in SCUBA |
About the gene
| Synonyms | MGC33971 |
|---|---|
| Chromosome | 4: 184088706-184221230 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet- activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.