CYGB+ Quiescent Fibroblast
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include CYGB (cytoglobin, marks a specific quiescent fibroblast subset), UNC5B (netrin receptor expressed in stromal/vascular cells), RBP1 (retinol binding protein, marks subepithelial fibroblasts), NCAM1 (neural cell adhesion molecule, expressed in stromal cells), FGFR4, FARP1 (Rho GEF), and PDK4 (metabolic switch enzyme). CYGB and RBP1 together are well-established markers of a quiescent intestinal fibroblast subpopulation (S1-type). Strongly downregulated in UC inflammation and restored in remission. NOVA1 and NCAM1 add neural-like features typical of this fibroblast subset.
Genes
CCND1, CYGB, FARP1, FGFR4, FXYD5, NCAM1, NEGR1, NOVA1, PDK4, PKDCC, PLEKHH2, RBP1, TRIL, UNC5B
Most correlated modules
- COL13A1+ Deep Fibroblast · correlation 0.83
- Homeostatic Fibroblast State · correlation 0.71
- WNT4+ Stromal Fibroblast · correlation 0.64
- BMP-Wnt Fibroblast Program · correlation 0.62
- Stromal Niche Signaling · correlation 0.57
- ASPN+ Submucosal Fibroblast · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.