WNT-modulating Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
PDGFRA is a canonical marker of intestinal subepithelial fibroblasts/telocytes. WNT5B and FRZB (WNT antagonist/decoy receptor) and KREMEN1 (DKK co-receptor that inhibits WNT) define a WNT pathway modulatory program. COL4A5, F3, PLAT, SEMA4D, and HSD17B2 support a stromal fibroblast identity. This module likely marks a PDGFRA+ subepithelial fibroblast subtype that actively modulates WNT signaling in the intestinal crypt niche. Down in inflammation, up in remission, consistent with homeostatic stromal identity.
Genes
CIB2, COL4A5, DMKN, F3, FIP1L1, FRZB, GPSM3, HSD17B2, INSC, KREMEN1, LRP4, NSG1, PDGFRA, PLAT, RFLNB, SCUBE1, SEMA4D, WNT5B
Most correlated modules
- Myofibroblast Subtype · correlation 0.95
- Fibroblast Niche Identity · correlation 0.93
- Intestinal Fibroblast Identity · correlation 0.92
- Telocyte Identity Program · correlation 0.86
- Thrombin Receptor Signaling · correlation 0.85
- ECM Glycan Remodeling · correlation 0.80
- Caveolae Mechanosensing · correlation 0.80
- Metabolic Homeostasis · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.