Proteasome Biogenesis
Gene co-expression module in Fibroblasts
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
POMP (proteasome maturation protein) is the top hub and is the dedicated chaperone required for 20S proteasome assembly — it directly links to the proteasome subunits in neighboring modules M6 and M7. SEC61B and SEC61G encode the beta and gamma subunits of the SEC61 translocon, the main protein-conducting channel of the ER membrane. SNRPG, SNRPD1, and SNRPE are Sm snRNP proteins involved in pre-mRNA splicing. EIF5A is a translation elongation factor. NOP10 is involved in ribosome biogenesis and telomerase. MRPL14 is a mitoribosomal protein. NME1 is a nucleoside diphosphate kinase. The co-expression of POMP with SEC61 subunits and splicing factors suggests a general proteostasis/biosynthetic capacity module. The strong inflammation upregulation and neighbor context (proteasome subunits in M6, M7) support proteasome biogenesis as the defining program, with SEC61 reflecting coupled ER import demand.
Genes
EIF5A, MRPL14, NME1, NOP10, POMP, SEC61B, SEC61G, SNRPD1, SNRPE, SNRPG
Most correlated modules
- Proteasome Assembly · correlation 0.97
- ER Protein Processing · correlation 0.95
- Lysosomal Stress Response · correlation 0.94
- Cullin-RING Ubiquitin Ligase · correlation 0.94
- ER-Golgi Trafficking · correlation 0.93
- ER Secretory Processing · correlation 0.93
- Proteasome & OxPhos · correlation 0.92
- Mitochondrial Energy Metabolism · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.