TNFRSF12A — TNF receptor superfamily member 12A
TNFRSF12A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFRSF12A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, PLAUR +4 more | View in SCUBA |
| Glial cells | Inflammatory Cytokine Signaling Inflammation | BACH1, BTG3, CSF1, FSTL3, NNMT, PAPPA, PDPN, RAB13 +3 more | View in SCUBA |
| Monocytes | Integrin-mediated Migration Migration & adhesion | DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1 +7 more | View in SCUBA |
About the gene
| Synonyms | CD266, FN14, TweakR |
|---|---|
| Chromosome | 16: 3018445-3022383 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Receptor |
| Biological process | Angiogenesis, Apoptosis, Cell adhesion, Differentiation |
Function
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.