PLAUR — Plasminogen activator, urokinase receptor
PLAUR belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLAUR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Stress Response Inflammation | ADI1, APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2 +11 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, SELENOS +4 more | View in SCUBA |
| Goblet cells | Basement Membrane Remodeling migration & adhesion | AHNAK, CD55, CYP3A5, F3, GPRC5A, LAMA3, LAMB3, LAMC2 +7 more | View in SCUBA |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
| Neutrophils | NF-κB Activation Inflammatory | EHD1, GRAMD1A, NBN, NFKB2, NFKBIA, NFKBIZ, PLEK, PLK3 +6 more |
About the gene
| Synonyms | CD87, UPAR, URKR |
|---|---|
| Chromosome | 19: 43646095-43670547 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.