SCUBA

SUSD6 — Sushi domain containing 6

SUSD6 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SUSD6's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsActomyosin signaling
migration & adhesion
ACIN1, CYBC1, EIF4G3, GALNT1, HNRNPA3, NCKAP1L, PPP1R12A, PRKCH +8 moreView in SCUBA
EndothelialVEGF Tip Cell Signaling
Endothelial cell development
ADAMTS5, BDKRB2, CA2, CBLB, CCND1, DGKD, ESM1, GABRD +7 moreView in SCUBA
EnterocytesEpithelial junction polarity
Migration & adhesion
CXADR, FRMD3, IL13RA1, KIF3B, MARVELD3, NEDD9, PTPRD, RAB6A +5 moreView in SCUBA
FibroblastsInflammatory Fibroblast Activation
Inflammatory
CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, PLAUR +4 moreView in SCUBA
Gamma-delta T cellsMitochondrial RNA Processing
Mitochondrial & OxPhos
ABR, DARS1, DENND1C, GTDC1, MRPS30, PDCD4, PMPCB, POLG +11 more
Innate lymphoid cellsNK/ILC1 Identity
Differentiation
ABCA5, ARHGAP15, CD37, CD96, CD99, CTSD, EPC1, GIMAP2 +17 moreView in SCUBA
MacrophagesSphingolipid Membrane Homeostasis
Lipid metabolism
ACER3, AGPAT3, ARHGEF11, ATP2A2, C9orf72, CMIP, DMXL2, DOCK8 +12 moreView in SCUBA
NeutrophilsPI3K Chemotaxis Signaling
Chemotaxis
ABCA1, ACSL1, ALDH1A2, CRK, INPP5A, LIMK2, NUP98, PIK3R5 +6 more

About the gene

SynonymsKIAA0247
Chromosome14: 69611596-69715144
Predicted locationMembrane
Essential geneNo
Protein classPredicted membrane proteins

Function

May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium. Plays a role in preventing tumor onset (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.