TUBA1C — Tubulin alpha 1c

TUBA1C belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

TUBA1C's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	G2/M Mitosis Cell cycle	AURKA, BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, CENPA +7 more	View in SCUBA
CD4⁺ T cells	NF-kB activation TCR/AP1/NFKb pathway	ADRA2B, CD83, CHD4, CYB5D1, DUSP2, EGR2, EGR3, EGR4 +9 more	View in SCUBA
CD8⁺ T cells	Mitotic Spindle Cell cycle	ASPM, BUB1, CENPA, CENPE, CENPF, DLGAP5, GTSE1, HMMR +6 more	View in SCUBA
Fibroblasts	Inflammatory Fibroblast Activation Inflammatory	CISD1, HRH1, HSPA5, ITGA5, LHFPL2, MAPKAPK2, PDPN, PLAUR +4 more	View in SCUBA
Gamma-delta T cells	G1/S Entry Cell cycle	CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more
Lymphatic endothelial	NRF2 Oxidative Stress Stress	B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2 +11 more	View in SCUBA
Macrophages	Ribosome Biogenesis Housekeeping	ABCE1, BCCIP, CLPX, COX20, DDX18, DUS1L, EIF3B, IDH3A +17 more	View in SCUBA
Mucosal-associated invariant T cell	Anti-inflammatory Homing Tissue residence	ANXA1, GPR183, NASP, PNP, TAGLN2, UBE2A, VIM, YWHAQ
Natural Killer cells	S/G2M Cell Cycle Cell cycle	CALM2, CDK2AP2, CKS2, JPT1, KPNA2, NAP1L1, NASP, PRDX1	View in SCUBA

About the gene

Synonyms	bcm948, MGC10851, MGC14580, TUBA6
Chromosome	12: 49188736-49274600
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.