OSM Cytokine Response
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
OSMR (oncostatin M receptor) is a canonical marker of inflammation-activated fibroblasts in IBD, strongly upregulated by OSM from macrophages. ARID5B is a transcriptional co-activator downstream of IL-6/STAT3 signaling. FGF7 is a fibroblast-secreted epithelial growth factor upregulated in inflammation. ELK3 is an ETS transcription factor activated by MAPK/inflammatory signals. PDE4B regulates cAMP in inflammatory contexts. PTGER1 is a prostaglandin E2 receptor mediating inflammatory responses. The very strong UC inflammation delta (0.534) and reversal with remission confirm an inflammatory cytokine-response program. This module likely represents OSM/IL-6-driven fibroblast activation.
Genes
ARID5B, ELK3, FGF7, OSMR, PDE4B, PTGER1, RNF145, UFM1
Most correlated modules
- Proteolytic Fibroblast State · correlation 0.76
- Inflammatory ECM Remodeling · correlation 0.76
- Stromal Fibroblast Activation · correlation 0.75
- Interferon Response · correlation 0.74
- Inflammatory Fibroblast Activation · correlation 0.72
- ER Stress UPR · correlation 0.71
- NFAT-cAMP Signaling · correlation 0.68
- Homeostatic Fibroblast Identity · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.