Interferon Response
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 14 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes IFI16 (innate immune DNA sensor, interferon-stimulated gene), TRIM22 (interferon-stimulated E3 ubiquitin ligase), PLSCR1 (interferon-stimulated phospholipid scramblase), SAMHD1 (interferon-stimulated dNTPase/antiviral), IFI6 (interferon alpha-inducible), and CCL7 (chemokine) define a type I/II interferon response program. BASP1 (brain acid soluble protein, also ISG-associated), CLEC2B (C-type lectin, immune), TNFSF10 (TRAIL, interferon-inducible apoptosis ligand), ABCA1 (cholesterol transporter, also ISG), and S1PR2 (sphingosine-1-phosphate receptor, immune cell trafficking) are consistent with an interferon-driven inflammatory state. SRGAP1 and ABHD17C are less canonical. The module shows significant downregulation in UC inflammation (paradoxically), but the gene composition is clearly interferon-response. This may reflect a specific fibroblast subpopulation activated by interferon signaling.
Genes
A4GALT, ABCA1, ABHD17C, BASP1, CCL7, CLEC2B, IFI16, IFI6, PLSCR1, S1PR2, SAMHD1, SRGAP1, TNFSF10, TRIM22
Most correlated modules
- Homeostatic Fibroblast Identity · correlation 0.84
- CCL11 Secretory Fibroblast · correlation 0.81
- Inflammatory Fibroblast Activation · correlation 0.77
- OSM Cytokine Response · correlation 0.74
- Stromal Fibroblast Activation · correlation 0.69
- Stromal Niche Signaling · correlation 0.65
- Cytokine Chemokine Secretion · correlation 0.65
- BMP-ECM Fibroblast · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.