OSMR — Oncostatin M receptor
OSMR belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSMR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CCNY, CFLAR, F11R +13 more | View in SCUBA |
| Fibroblasts | OSM Cytokine Response Inflammatory | ARID5B, ELK3, FGF7, PDE4B, PTGER1, RNF145, UFM1 | View in SCUBA |
| Pericytes | NF-κB Inflammatory Activation Inflammatory | CTSS, EFHD2, HIF1A, IL32, LAP3, TAPBP, TMEM165 | View in SCUBA |
| Smooth muscle cells | ER Chaperone/UPR Protein processing & ER | CALR, CRISPLD2, FBLIM1, HIF1A, HSP90B1, HSPA5, IL6ST, PCOLCE +3 more | View in SCUBA |
About the gene
| Synonyms | OSMRB, OSMRbeta |
|---|---|
| Chromosome | 5: 38845858-38945596 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.