Homeostatic Fibroblast Identity
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 15 genes have a known function matching the annotation |
Why this annotation
Top hub genes LUM (lumican, proteoglycan), DCN (decorin, proteoglycan), DKK3 (Wnt antagonist expressed in stromal fibroblasts), IL6ST (gp130, IL-6 family receptor), VCAM1 (adhesion molecule), and C1S (complement) define a canonical intestinal stromal fibroblast identity program. PMP22 is expressed in fibroblasts/Schwann-like cells. IL34 is a CSF1R ligand involved in macrophage support. RFTN1, ADGRL2, DPYSL2, ST8SIA1, PARM1, TMSB4X/TMSB10 are consistent with a mature fibroblast state. The high mean expression (1.176) and 47% detection rate indicate a broadly expressed homeostatic fibroblast program. This module is a neighbor to M51 and M132, all representing homeostatic fibroblast states. LUM and DCN are classical ECM proteoglycans produced by fibroblasts.
Genes
ADGRL2, C1S, DCN, DKK3, DPYSL2, IL34, IL6ST, LUM, PARM1, PMP22, RFTN1, ST8SIA1, TMSB10, TMSB4X, VCAM1
Most correlated modules
- Interferon Response · correlation 0.84
- CCL11 Secretory Fibroblast · correlation 0.82
- Complement-secreting Fibroblast · correlation 0.79
- Stromal Niche Signaling · correlation 0.79
- Microfibril ECM Fibroblast · correlation 0.78
- Stromal Fibroblast Activation · correlation 0.77
- Subepithelial Fibroblast · correlation 0.76
- BMP-ECM Fibroblast · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.