PLZF Innate-like Effector
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
ZBTB16 (PLZF) is the master transcription factor for innate-like T lymphocytes including Vγ9Vδ2 γδ T cells, driving an effector-primed differentiation state acquired during thymic development. HNRNPLL mediates alternative splicing transitions during T cell activation and maturation. DUSP16 regulates MAPK/TCR signaling intensity. PERP links to apoptosis-resistance in effector cells. Together these genes define the PLZF-driven innate-like effector differentiation program characteristic of γδ T cells.
Genes
DUSP16, GALM, GRAMD1B, HNRNPLL, MKNK1, NIBAN1, PBX4, PERP, SYNJ2, ZBTB16
Most correlated modules
- TCR Signal Regulation · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.