GRAMD1B — GRAM domain containing 1B
GRAMD1B belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GRAMD1B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GTDC1, ITGA4 +8 more | View in SCUBA |
| Enterocytes | Sterol Transfer Lipid metabolism | CAPN13, GAREM1, MTARC2, NBAS, OSBPL9, PRLR | View in SCUBA |
| Gamma-delta T cells | PLZF Innate-like Effector T cell maturation | DUSP16, GALM, HNRNPLL, MKNK1, NIBAN1, PBX4, PERP, SYNJ2 +1 more | |
| Mucosal-associated invariant T cell | T cell Quiescence T cell maturation | AGO2, AUTS2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1 +13 more |
About the gene
| Synonyms | KIAA1201, LINC01059 |
|---|---|
| Chromosome | 11: 123358428-123627774 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Lipid transport, Transport |
Function
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.