MKNK1 — MAPK interacting serine/threonine kinase 1
MKNK1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MKNK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | PLZF Innate-like Effector T cell maturation | DUSP16, GALM, GRAMD1B, HNRNPLL, NIBAN1, PBX4, PERP, SYNJ2 +1 more | |
| Macrophages | Mixed Regulatory Signaling Housekeeping | ADAP2, AKAP11, ARHGAP17, ARHGAP27, BLTP2, BLTP3A, C2CD2L, COG2 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Homeostasis T cell maturation | APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, IL7R +19 more | |
| Neutrophils | TLR2 Innate Signaling Innate immunity | AATK, CHST15, CYRIA, DHX34, ECE1, ERGIC1, MAP4K4, STK40 +4 more |
About the gene
| Synonyms | MNK1 |
|---|---|
| Chromosome | 1: 46557407-46616843 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Translation regulation |
Function
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine- containing mRNA cap.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.