GALM — Galactose mutarotase

GALM belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

GALM's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	OxPhos & proteasome Mitochondrial & OxPhos	CCDC167, CLTA, COX17, COX5A, DBI, FKBP1A, FMNL1, MRPL41 +10 more	View in SCUBA
CD8⁺ T cells	Tumor mediated exhaustion Exhaustion	ANXA6, CXCL13, HNRNPLL, IFNG, ITM2A, PDCD1, PTPN7, SARDH +3 more	View in SCUBA
Enterocytes	Mitochondrial Energy Metabolism Mitochondrial & OxPhos	ALDH1A1, ALDH3A2, CPS1, GCNT1, GPI, GSTM4, MTCH2, NDUFV1 +2 more	View in SCUBA
Gamma-delta T cells	PLZF Innate-like Effector T cell maturation	DUSP16, GRAMD1B, HNRNPLL, MKNK1, NIBAN1, PBX4, PERP, SYNJ2 +1 more

About the gene

Chromosome	2: 38666081-38741237
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Isomerase
Biological process	Carbohydrate metabolism

Function

Mutarotase that catalyzes the interconversion of beta-D- galactose and alpha-D-galactose during galactose metabolism. Beta-D-galactose is metabolized in the liver into glucose 1-phosphate, the primary metabolic fuel, by the action of four enzymes that constitute the Leloir pathway: GALM, GALK1 (galactokinase), GALT (galactose-1-phosphate uridylyltransferase) and GALE (UDP-galactose-4'-epimerase). Involved in the maintenance of the equilibrium between the beta- and alpha-anomers of galactose, therefore ensuring a sufficient supply of the alpha-anomer for GALK1. Also active on D-glucose although shows a preference for galactose over glucose

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.