PERP — P53 apoptosis effector related to PMP22
PERP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PERP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine receptor signaling Immune regulation | C21orf91, C6orf62, DDX3X, HNRNPH1, ID2, IL15RA, IL18RAP, MMD +1 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | ADAM23, AGPAT2, CLDN5, ECHDC2, GOLGA8B, HHEX, LY6E, NDN +1 more | View in SCUBA |
| Gamma-delta T cells | PLZF Innate-like Effector T cell maturation | DUSP16, GALM, GRAMD1B, HNRNPLL, MKNK1, NIBAN1, PBX4, SYNJ2 +1 more | |
| Goblet cells | Epithelial Junction Integrity migration & adhesion | ACTR2, ANXA2, CTNNA1, DSC2, GLUL, SERPINB1, TNFSF10 | View in SCUBA |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ALOX5AP, CNOT7, COMMD10, ELAVL1, FKBP8, FNTA, IFI27L2, IL32 +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | Retinoic Acid Response Tissue residence | C16orf54, CHRAC1, EHD1, MRPL10, NDRG1, RALGDS, RARA |
About the gene
| Synonyms | dJ496H19.1, KCP1, KRTCAP1, PIGPC1, THW |
|---|---|
| Chromosome | 6: 138088505-138107419 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Cell adhesion |
Function
Component of intercellular desmosome junctions (By similarity). Plays a role in stratified epithelial integrity and cell- cell adhesion by promoting desmosome assembly (By similarity). Thereby plays a role in barrier function of the skin against infection (By similarity). Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions (By similarity). Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis (By similarity). May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4 (By similarity). Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity). Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling (By similarity). Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8. Required for neutrophil transepithelial migration in response to S.typhimurium infection. May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.