ZBTB16 — Zinc finger and BTB domain containing 16

ZBTB16 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ZBTB16's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Naive B cell B cell maturation	ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more	View in SCUBA
Gamma-delta T cells	PLZF Innate-like Effector T cell maturation	DUSP16, GALM, GRAMD1B, HNRNPLL, MKNK1, NIBAN1, PBX4, PERP +1 more
Innate lymphoid cells	mRNA Translation RNA processing & translation	ABHD14B, ARHGDIA, CD2BP2, EEF2, EIF3L, GYPC, H2AJ, HNRNPA0 +6 more	View in SCUBA
Monocytes	Glucocorticoid Transcription Inflammatory	HECTD1, JDP2, KLF13, KLF9, PER1, PIK3R1, TMEM123	View in SCUBA
Mucosal-associated invariant T cell	MAIT Cell Identity T cell maturation	AFF3, DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1 +16 more
Natural Killer cells	NK/ILC Differentiation Differentiation	ARHGAP9, CHKA, CHPT1, PIM2, PITPNC1, PPP1R16B, STAM	View in SCUBA
Neutrophils	Immature Granulocyte Progenitor Developmental	ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MAOA +3 more
Smooth muscle cells	Glucocorticoid Metallothionein Response Stress	CEBPB, CEBPD, FKBP5, MT1E, MT1M, MT1X, MT2A, PNRC1 +3 more	View in SCUBA

About the gene

Synonyms	PLZF, ZNF145
Chromosome	11: 114059041-114256765
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation, Ubl conjugation pathway

Function

Acts as a transcriptional repressor. Transcriptional repression may be mediated through recruitment of histone deacetylases to target promoters. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.