DUSP16 — Dual specificity phosphatase 16
DUSP16 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUSP16's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | MAPK feedback signaling TCR/AP1/NFKb pathway | BACH1, DUSP4, E2F3, EPSTI1, MAT2B, PELI1, PIM2, SEC14L1 +2 more | View in SCUBA |
| Gamma-delta T cells | PLZF Innate-like Effector T cell maturation | GALM, GRAMD1B, HNRNPLL, MKNK1, NIBAN1, PBX4, PERP, SYNJ2 +1 more | |
| Mucosal-associated invariant T cell | TCR Signal Attenuation Immune regulation | AFF4, BORCS5, CENPC, CHD2, CRACR2A, CRYBG1, FAS, FNBP1 +8 more |
About the gene
| Synonyms | KIAA1700, MKP-7, MKP7 |
|---|---|
| Chromosome | 12: 12473282-12562863 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.