PDE8A — Phosphodiesterase 8A
PDE8A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDE8A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | SPP1 Inflammatory Activation Inflammation | ADAM15, ATG4A, C1orf54, C7orf50, C9orf40, CPXM2, EBF3, EIF2AK4 +9 more | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2 +19 more | |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | DYRK1A, HERC1, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, NCOA1 +2 more | View in SCUBA |
| Macrophages | Innate Immune Dampening Innate immunity | DCAF6, ELL2, FGD4, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2 +10 more | View in SCUBA |
About the gene
| Synonyms | HsT19550 |
|---|---|
| Chromosome | 15: 84980440-85139145 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory- phosphorylation and stimulates RAF1-dependent EGF-activated ERK- signaling. Protects against cell death induced by hydrogen peroxide and staurosporine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.