MAP3K1 — Mitogen-activated protein kinase kinase kinase 1
MAP3K1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP3K1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Regulation DNA/chromatin regulation | AKAP9, ANKRD12, BBX, CHD2, CHD7, IRF1, KDM7A, L3MBTL3 +8 more | View in SCUBA |
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D +17 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | CCDC71L, FABP4, LAPTM5, MDK, PCBD1, PMVK, RASSF4, SCNN1B +2 more | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FCHSD2 +19 more | |
| Lymphatic endothelial | Hypoxia Response Stress | CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B +11 more | View in SCUBA |
| Macrophages | Myeloid Receptor Signaling Innate immunity | ADGRE5, ANKFY1, ANKIB1, ATP1B1, CPT1A, DNAJC13, DOCK7, EPS15 +29 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, GAPT, LYST, MNDA, POU2F2, RGS18, SLC24A4, TMEM154 +4 more | View in SCUBA |
About the gene
| Synonyms | MAPKKK1, MEKK, MEKK1 |
|---|---|
| Chromosome | 5: 56815549-56896152 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.