TNFSF14 — TNF superfamily member 14
TNFSF14 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNFSF14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell co-receptors T cell development | AGO4, ARRB2, CAPG, CD200R1, CD40LG, CD96, EMB, FKBP11 +13 more | View in SCUBA |
| Fibroblasts | NF-κB Inflammatory Activation Inflammatory | BIRC3, CD40, CTSS, DRAM1, HAPLN3, IL15RA, IL32, LAP3 +5 more | View in SCUBA |
| Gamma-delta T cells | XCL1/XCL2 Cytotoxic Activation cytotoxicity | BCL2A1, CCL3L3, CCL4L2, FASLG, ICAM1, IRF8, PLEKHO2, RILPL2 +6 more | |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | ACADVL, APOL3, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1 +4 more |
About the gene
| Synonyms | CD258, HVEM-L, LIGHT, LTg |
|---|---|
| Chromosome | 19: 6661253-6670588 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
Function
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.