TRAF1 — TNF receptor associated factor 1
TRAF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, MDFIC, NSUN6, PMAIP1 +6 more | View in SCUBA |
| Gamma-delta T cells | XCL1/XCL2 Cytotoxic Activation cytotoxicity | BCL2A1, CCL3L3, CCL4L2, FASLG, ICAM1, IRF8, PLEKHO2, RILPL2 +6 more | |
| Monocytes | TNF/IL-1 Cytokine Storm Inflammatory | CCL3, CCL4, CCL4L2, EGR3, IL1A, IL6, KCNJ2, PTGS2 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Effector Activation Inflammation | ADGRE5, BCL2A1, CCL20, CCL3, CCL3L3, CCL4, CCL4L2, DUSP10 +10 more |
About the gene
| Synonyms | EBI6 |
|---|---|
| Chromosome | 9: 120902393-120929173 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Biological process | Apoptosis |
Function
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin- protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.