Naïve T Cell
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes CCR7, LEF1, BACH2, RTKN2, INPP4B, TRABD2A, and NELL2 are canonical markers of naïve/central memory T cell identity and quiescence. CCR7 mediates lymph node homing, LEF1 maintains naïve T cell identity, BACH2 enforces naïve quiescence, RTKN2 and INPP4B suppress PI3K-driven differentiation. Together they define a naïve T cell transcriptional program within γδ T cells.
Genes
ADK, AIF1, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, DPYD, FAM117B, FUT8, IL4R, INPP4B, LEF1, NELL2, RTKN2, TRABD2A
Most correlated modules
- Naïve T Cell State · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.