NELL2 — Neural EGFL like 2
NELL2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NELL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Gamma-delta T cells | Naïve T Cell T cell maturation | ADK, AIF1, ARHGAP15, ARMH1, BACH2, CCR7, CNR2, DPYD +7 more | |
| Mucosal-associated invariant T cell | Cytotoxic Effector cytotoxicity | ANXA4, CCM2, CD320, CST7, DYNLRB1, GZMM, LIMD2, MCUB +10 more |
About the gene
| Synonyms | NRP2 |
|---|---|
| Chromosome | 12: 44508275-44921848 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Biological process | Neurogenesis |
Function
Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline. Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). Epididymal-secreted protein that signals through a ROS1- pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.